This article presents the results of an investigation aimed at evaluating the early and late outcomes of surgical treatment in patients with perforated diverticulitis and purulent peritonitis who underwent laparoscopic or open colon resection. A retrospective non-randomized comparative study was conducted on 86 patients. The main group consisted of 40 patients who underwent laparoscopic colon resection with stoma formation, while the control group included 46 patients who underwent open surgery. The investigations revealed that the incidence of postoperative complications was lower in the main group (32.5% versus 56.5%, p<0.05). The frequency of reconstructive and restorative operations after laparoscopic resection was higher (84.2% versus 36.6%, p<0.001). The recurrence of complications of diverticular disease after laparoscopic resection occurred in 18.4%, while after open resection, it was 61% (p<0.001). Thus, the use of laparoscopic access for colon resection in patients with perforated diverticulitis demonstrated higher safety and efficacy compared to open resection. © 2023 Ministry of Health. All rights reserved.