In this article, we present a clinical case of staged treatment of a patient with lung cancer and a thoracic aortic aneurysm. At the first stage, the patient underwent an extended upper lobectomy on the right with resection of the apical segment of the lower lobe of the lung and mediastinal lymph node dissection. At the second stage, a hybrid operation was performed, including partial debranching of the aortic arch and endovascular thoracic aortic aneurysm repair. The chosen approach made it possible to reduce the overall traumaticity of surgical interventions, while maintaining the radical nature of treatment. This clinical example is an illustration of the fact that the modern hybrid strategy for the treatment of thoracic aortic pathology (in particular, the aortic arch) significantly expands the possibilities of treating patients with combined pathology, allowing to reduce the risks of both general surgical complications and cerebral circulation impairments. However, the place of this approach can only be determined after assessing the long-term results, in particular the risks and frequency of aortic remodeling. © 2023, Geotar Media Publishing Group. All rights reserved.