A review of the literature on the link of various types of smoke and solar activity with human neoplasms is presented. The significance of benign and malignant neoplasms in young children aged 0-4 years as an indicator of carcinogenic effects on the population is shown. Information about the oncogenic potential of all types of smoke, including exhaust gases, tobacco smoke and smoke from forest fires is provided. The special danger of vehicle exhaust gases is indicated in connection with the content of benzene, which is a proven human carcinogen. There is extensive evidence linking various types of smoke with the development of leukemia, Hodgkin's lymphoma, non-Hodgkin's lymphomas, multiple myeloma, retinoblastoma, neuroblastoma, hepatoblastoma, hemangiomas, and tumors of the central nervous system. Data on the connection between solar activity, in particular ultraviolet radiation, and the risk of leukemia, lymphomas as well as such neoplasms in young children aged 0-4 years as nephroblastoma, hemangioma, benign tumors and soft tissue sarcomas are highlighted. The possible role of geomagnetic field fluctuations in the genesis of hemoblastoses in children and adults is considered. The importance of ecologically determined oxidative stress in the realization of the oncogenic potential of environmental factors is shown. Possible measures for the prevention of neoplasms by reducing the intensity of human exposure to environmental factors, as well as methods for stopping oxidative stress, are considered. Recommendations on increasing the effectiveness of antioxidant protection by stimulating autophagy through the introducing various plant components, alkylcatechols into the diet, and correcting immunodeficiency with transfer factor are given. © Eco-Vector, 2022. All rights reserved.