MOLECULAR BASIS OF BIOLOGICAL ACTIVITY OF POLYSACCHARIDES IN COVID-19 ASSOCIATED CONDITIONS; [МОЛЕКУЛЯРНЫЕ ОСНОВЫ БИОЛОГИЧЕСКОЙ АКТИВНОСТИ ПОЛИСАХАРИДОВ ПРИ АССОЦИИРОВАННЫХ С COVID-19 СОСТОЯНИЯХ]

The review considers the main molecular biological features of the COVID-19 causative agent, the SARS-CoV-2 virus: life cycle, viral cell penetration strategies, interactions of viral proteins with human proteins, cytopathic effects. We also analyze pathological conditions that occur both during the course of the COVID-19 disease and after virus elimination. A brief review of the biological activities of polysaccharides isolated from various sources is given, and possible molecular biological mechanisms of these activities are considered. Data analysis shows that polysaccharides are a class of biological molecules with wide potential for use in the treatment of both acute conditions in COVID-19 and post-COVID syndrome. © 2022 Russian Academy of Medical Sciences. All rights reserved.