Triglyceride-glucose index (TyG) as a novel biomarker in the era of cardiometabolic medicine

In the period of increasing prevalence of metabolic disorders such as obesity and diabetes, healthcare professionals are facing significant challenges. Therefore, an accurate global assessment of insulin resistance is of utmost importance. Current medical research is focused on identifying an easily accessible and reproducible gold-standard surrogate marker for insulin resistance. Ideally, such a marker would enable healthcare providers to predict the risk of type 2 diabetes and cardiovascular diseases. The triglyceride-glucose index (TyG) is a promising marker for preventive cardiology and cardiometabolic medicine. This narrative review article aims to provide a comprehensive evaluation of the credibility of TyG as a surrogate marker of insulin resistance among patients at different stages across the cardiometabolic continuum. This assessment fully complies with evidence-based medicine and offers valuable insight into the clinical utility of TyG. © 2024

Авторы
Avagimyan A. , Pogosova N. , Fogacci F. , Aghajanova E. , Djndoyan Z. , Patoulias D. , Sasso L.L. , Bernardi M. , Faggiano A. , Mohammadifard N. , Neglia D. , Carugo S. , Cicero A. , Rizzo M. , Biondi-Zoccai G. , De Caterina R. , Sarrafzadegan N.
Журнал
International Journal of Cardiology
Язык
Английский
Статус
Опубликовано
Ссылка
Внешняя ссылка
DOI
10.1016/J.IJCARD.2024.132663
Номер
132663
Том
418
Год
2025
Организации
  • 1 Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  • 2 Deputy Director of Research and Preventive Cardiology, National Medical Research Centre of Cardiology named after E. Chazov, Moscow, Russian Federation
  • 3 Head of Evidence-Based Medicine Department, Institute of Medicine, Peoples' Friendship University of Russia (RUDN), Moscow, Russian Federation
  • 4 Atherosclerosis and Metabolic Disorders Research Unit, University of Bologna, Bologna, Italy
  • 5 Head of Endocrinology Department, Head of Endocrinology Unit of Muratsan University Clinic, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
  • 6 Head of Internal Diseases Propaedeutics Department, Head of Internal Diseases Unit, Mikaelyan University Clinic, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
  • 7 Outpatient Department of Cardiometabolic Medicine, Second Department of Cardiology, General Hospital “Hippokration”, Aristotle University of Thessaloniki, Thessaloniki, Greece
  • 8 Catholic University of the Sacred Heart, Rome, Italy
  • 9 Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy
  • 10 Department of Cardio-Thoracic-Vascular Area, Foundation IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy
  • 11 Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
  • 12 Head of Nutrition Department, Cardiovascular Research Institute the WHO Collaborative Centre, Isfahan University of Medical Sciences, Isfahan, Iran
  • 13 Cardiovascular Department, CNR Research Area, Fondazione CNR/Regione Toscana Gabriele Monasterio, Pisa, Italy
  • 14 Hypertension and Cardiovascular Risk Research Unit, Medical and Surgical Sciences Department, Alma Mater Studiorum University of Bologna, Bologna, Italy
  • 15 Cardiovascular Medicine Unit, IRCCS Policlinico S. Orsola-Malpighi di Bologna, Bologna, Italy
  • 16 Head of Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, School of Medicine, University of Palermo, Italy
  • 17 Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU), Dubai, United Arab Emirates
  • 18 Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy
  • 19 Head of Cardiology Department, University of Pisa, Pisa, Italy
  • 20 Director of Cardiovascular Research Institute WHO Collaboration Centre, Isfahan University of Medical Sciences, Isfahan, Iran
  • 21 School of Population and Public Health, Faculty of Medicine, University of British Columbia, Vancouver, Canada
Ключевые слова
Cardiodiabetology; Cardiovascular risk; Glucose; Triglyceride-glucose index; Triglycerides; TyG
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