Bismuth Nanoparticles Increase Effectiveness of Proton Therapy of Ehrlich Carcinoma

We studied the antitumor activity of the combined use of local proton irradiation in two modes (10 and 31 Gy) with preliminary intra-tumoral injection of two types of bismuth nanoparticles differing in surface coating: coated with the amphiphilic molecule Pluronic-F127 or Silane-PEG (5 kDa)-COOH polymer. Nanoparticles were used in doses of 0.75 and 1.5 mg/mouse. In two independent series on experimental tumor model (solid Ehrlich carcinoma), bismuth nanoparticles of both modifications injected directly into the tumor enhanced the antitumor effects of proton therapy. Moreover, the radiosensitizing effect of bismuth nanoparticles administered via this route increased with the increasing the doses of nanoparticles and the doses of radiation exposure. In our opinion, these promising data obtained for the first time extend the possibilities of treating malignant neoplasms. © Springer Science+Business Media, LLC, part of Springer Nature 2024.

Авторы
Filimonova M.V. , Soldatova O.V. , Shitova A.A. , Filimonov A.S. , Rybachuk V.A. , Kosachenko A.O. , Nikolaev K.A. , Demyashkin G.A. , Popov A.A. , Zelepukin I.V. , Kabashin A.V. , Deev S.M. , Kaprin A.D. , Shegay P.V. , Ivanov S.A. , Zavestovskaya I.N. , Koryakin S.N.
Издательство
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Номер выпуска
5
Язык
Английский
Страницы
626-630
Статус
Опубликовано
Том
176
Год
2024
Организации
  • 1 A. Tsyb Medical Radiological Research Center — Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation, Obninsk, Russian Federation
  • 2 National Research Nuclear University MEPhI, Moscow, Russian Federation
  • 3 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
  • 4 Aix-Marseille University, Marseille, France
  • 5 P. N. Lebedev Physical Institute, Russian Academy of Sciences, Moscow, Russian Federation
  • 6 National Medical Research Radiological Centre, Ministry of Health of the Russian Federation, Moscow, Russian Federation
  • 7 Obninsk Institute for Nuclear Power Engineering, National Research Nuclear University MEPhI, Obninsk, Russian Federation
  • 8 Patrice Lumumba Peoples’ Friendship University of Russia, (RUDN University), Moscow, Russian Federation
Ключевые слова
antitumor effectiveness; nanoparticles; proton irradiation; radiosensitizers
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