Comparative Morphological and Molecular Genetic Characteristics of Cell and Tissue Strains of Experimental Rat Glioma 10-17-2 (Astrid-17)

In order to obtain models of gliomas of varying degrees of malignancy, we performed morphological and molecular genetic study of a tissue strain of glioma 10-17-2 (Astrid-17) obtained by intracranial passaging of tumor fragments of chemically induced rat brain tumor, and a cell strain isolated from it. More or less pronounced changes in the expression levels of Mki67, Trp53, Vegfa, and Gfap genes in the tissue and cell strain of glioma 10-17-2 (Astrid-17) compared with intact brain tissue were shown. The tissue model of glioma 10-17-2 (Astrid-17) according to the studied characteristics shows features of grade 3-4 astrocytoma and the cellular model — grade 2-3 astrocytoma. © Springer Science+Business Media, LLC, part of Springer Nature 2024.

Авторы
Alekseeva A.I. , Kudelkina V.V. , Khalansky A.S. , Sentyabreva A.V. , Miroshnichenko E.A. , Gulyaev M.V. , Rakitina K.A. , Kosyreva A.M.
Издательство
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Номер выпуска
1
Язык
Английский
Страницы
169-175
Статус
Опубликовано
Том
177
Год
2024
Организации
  • 1 Avtsyn Research Institute of Human Morphology, Petrovsky Russian Research Center of Surgery, Moscow, Russian Federation
  • 2 Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow, Russian Federation
  • 3 Medical Institute, RUDN University, Moscow, Russian Federation
Ключевые слова
Astrid-17; astrocytoma; astroglia; glioma; proliferation
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