Neural and Glial Regulation of Angiogenesis in CNS in Ischemic Stroke

CNS diseases associated with compromised blood supply and/or vascular integrity are one of the leading causes of mortality and disability in adults worldwide and are also among 10 most common causes of death in children. Angiogenesis is an essential element of regeneration processes upon nervous tissue damage and can play a crucial role in neuroprotection. Here we review the features of cerebral vascular regeneration after ischemic stroke, including the complex interactions between endothelial cells and other brain cell types (neural stem cells, astrocytes, microglia, and oligodendrocytes). The mechanisms of reciprocal influence of angiogenesis and neurogenesis, the role of astrocytes in the formation of the blood—brain barrier, and roles of microglia and oligodendrocytes in vascular regeneration are discussed. Understanding the mechanisms of angiogenesis regulation in CNS is of critical importance for the development of new treatments of neurovascular pathologies. © Springer Science+Business Media, LLC, part of Springer Nature 2024.

Авторы
Grinchevskaya L.R. , Salikhova D.I. , Silachev D.N. , Goldshtein D.V.
Издательство
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Номер выпуска
4
Язык
Английский
Страницы
528-533
Статус
Опубликовано
Том
177
Год
2024
Организации
  • 1 Research Institute of Molecular and Cellular Medicine, Medical Institute, RUDN University, Moscow, Russian Federation
  • 2 Research Centre for Medical Genetics, Moscow, Russian Federation
  • 3 A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russian Federation
Ключевые слова
angiogenesis; CNS blood vessels; neurovascular unit; regulation of angiogenesis in CNS; vascular regeneration
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