Topology-defined bioactive properties of porous Ti-6Al-4V scaffolds produced by laser powder bed fusion

The effect of the design of additively printed Ti porous structures on their bioactive properties is elucidated by in vitro testing. 3D-printed scaffolds with pores defined by several bioinspired triply periodic minimal surfaces as well as by a strut model have been engineered. Cell proliferation, angiogenesis and osteogenesis have been studied with the help of multipotent mesenchymal stromal cells. The elementary unit size and pore design can notably modify bioactive properties of porous structures. The models providing maximal bioactive activity of developed scaffolds are discussed. © 2024 Elsevier B.V.