Effects of Fractionated Proton Irradiation in Combination with 1-β-D-Arabinofuranosylcytosine on B16 Murine Melanoma In Vivo

Abstract: This study is a search for means of sensitization of malignant tumors to proton radiation among DNA damage repair inhibitors. It has been found that in the presence of 1-β-D-arabinofuranosylcytosine (AraC), five weekly proton irradiations at a total focal dose of 50 Gy lead to a more pronounced inhibition of B16 murine melanoma growth than the same irradiation without AraC (p < 0.05). This effect, associated with a decrease in the proliferative activity of cells in the general population and a decrease in the number of cancer stem cells specifically in the AraC+Protons group, is promising for further improvement of proton radiotherapy. © Pleiades Publishing, Ltd. 2024. ISSN 1547-4771, Physics of Particles and Nuclei Letters, 2024, Vol. 21, No. 6, pp. 1208–1218. Pleiades Publishing, Ltd., 2024.