The purpose of this review article is to determine the frequency of occurrence due to comorbidities, as well as age-related features. In the course of a systematic review of the literature, information was searched in Russian and English without time limits in the PubMed electronic database, GoogleScholar, Cyberleninka and in the literature lists of relevant studies and reviews. Full-text articles were selected that describes the incidence of exfoliative cheilitis in age groups; associated with various labor activities of patients, as well as in regions with a high prevalence of OCM diseases Included publications contained a description of this disease with clinical cases. The review reviewed 123 articles. After analyzing the literature according to the inclusion criteria, the total number of included publications was 23 publications. According to the studied literature, it can be assumed that exfoliative cheilitis is a fairly common disease in modern day-today dental practice and has a diverse etiology, therefore, the correct algorithm for primary diagnosis and routing of patients contributes to the formation of a correct clinical diagnosis. © 2023,Journal of International Dental and Medical Research.All Rights Reserved.