Wheat is among the staple cereal crops cultivated worldwide, the need for this product has increased due to the burgeoning population. However, this crop's productivity improvement is agriculture's main task. The current paper aimed at investigating the influence of three treatments: basic, intensive, and highly intensive on wheat growth in the Moscow region, 30 km from the capital using vegetation index (NDVI). The treatments contained fertilizers, fungicides, insecticides, herbicides, and growth regulators at different combinations and concentrations. A Sentinel-2 with a resolution of 10 m was used to monitor the change in the wheat crop during 2019. Yield performances, yield components, grain quality (measured through protein content), and Normalized Difference Vegetation Index (NDVI) were determined according to the tested treatments. The results showed that the high intensive treatment (T3) recorded high values in terms of wheat yield (3 t/ha) more than basic treatment (T1) and grain quality was superior. In addition, reasonable correlations between Normalized Difference Vegetation Index (NDVI), wheat yield, and grain quality were noted. The obtained results open real opportunities for crop management evaluation using remote sensing. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2023.