Purpose — to identify and substantiate the correlation between the inclination of the upper premolars and the inclination of the ankle. Materials and methods. In 101 subjects, the inclination of the first premolars in the upper jaw on the right and left relative to the plane of the upper jaw was measured. At the same time, the angle of inclination of the ankle relative to the plane of the horizon was measured. The angle of inclination of premolars was measured on coronal sections of cone beam computed tomography, which was carried out at the stage of diagnosis. Ankle inclination angle was measured visually using a photo protocol and a graphic ruler. That side of the angle, the value of which was <90°, was taken into account. For angles >90°, the adjacent angle was taken (i.e., 180 minus the angle of inclination). Next, the difference between the angles of inclination of the right tooth (RT) and the inclination of the foot on the right (AR) and on the left (AL), as well as between the angles of inclination of the left tooth (LT) and the inclination of the foot on the right (AR) and left (AL) was calculated. Based on the results obtained, division into groups was carried out: group I — RT-AR, group II — RT-AL, group III — LT-AR, group IV — LT-AL, the smallest value was revealed. Results. For group I, the average difference was 2.31° (CI 95% 1.31—3.50°), for initially acute angles it was 1.25° (0.75—1.75°), and for adjacent ones it was 2.95° (1.40—4.70°). For group IV (LT-AL), the average difference was 1.42° (0.79—2.21°), for acute corners 0.25° (0.00—0.63°), and for adjacent corners 2.00° (1.13—3.00°). For group II, the average difference was 1.90° (1.17—2.76°), for acute angles 1.93° (1.13—2.80°), and for adjacent angles 1.86° (0.71—3.36°). For group III, the average difference was 1.69° (0.88—2.56°), for acute angles 1.25° (0.50—2.38°), and for adjacent angles 2.13° (0.88—3.76°). Conclusion. According to the results of the study, it can be concluded that in most patients there is a correlation between the angle of inclination between of the upper first premolars and the ankle. On the homolateral side in group I and IV in 55.5% cases, on the heterolateral side in groups II and III in 44.5% of cases. © 2024 Izvestiya Instituta Matematiki i Informatiki Udmurtskogo Gosudarstvennogo Universiteta. All rights reserved.