Effects of Combined Exposure to Carbon Ions and Protons on the Pool of MCF-7 Breast Cancer Stem Cells In Vitro

We studied the effects of single and combined action of protons and carbon ions 12C6+ on the pool of MCF-7 human breast cancer stem cells. Single irradiation with a beam of protons or carbon ions had no significant effects on the relative number of cancer stem cells (CSC). The effects of combined irradiation in a total equieffective dose of 4 Gy depended on the sequence of exposure to ionizing radiations: the relative number of CSC did not change after irradiation with carbon ions and then with protons, but increased in the case of the reverse sequence. The most favorable result, i.e. a decrease in the CSC pool, was observed in the case of sequential irradiation with carbon ions and protons and their equal contribution to total equieffective dose. In this case, the absolute number of CSC decreased by on average 2.1 times in comparison with the control (p<0.05). The revealed regularities are of interest for the further development of new methods of radiation therapy. © 2023, Springer Science+Business Media, LLC, part of Springer Nature.

Авторы
Matchuk O.N. , Selivanova E.I. , Yakimova A.O. , Saburov V.O. , Solov’ev A.N. , Troshina M.V. , Litun E.V. , Koryakin S.N. , Pikalov V.A. , Abramova M.R. , Ivanov S.A. , Zamulaeva I.A.
Издательство
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Номер выпуска
1
Язык
Английский
Страницы
82-86
Статус
Опубликовано
Том
176
Год
2023
Организации
  • 1 A. F. Tsyb Medical Radiological Research Center — Affiliated Branch of the National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Obninsk, Russian Federation
  • 2 Joint Institute for Nuclear Research, Dubna, Russian Federation
  • 3 A. A. Logunov Institute of High Energy Physics, National Research Centre “Kurchatov Institute”, Protvino, Russian Federation
  • 4 Patris Lumumba Peoples’ Friendship University of Russia (RUDN University), Moscow, Russian Federation
Ключевые слова
breast cancer; cancer stem cells; carbon ions; ionizing radiation; protons
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