Octenidine hydrochloride - OCT (Octenisept) has the potential to be used as root canal irrigant due to its efficacy against Candida albicans and E. faecalis. OCT is good alternative to NaOCl and CHX. The purpose of this review article is to assess systematically the available scientific evidence about the effectiveness of using antiseptic solution “Octenisept” during endodontic treatment. The study of publications was produced in the electronic databases such as Google Scholar, PubMed during a systematic review of the literature. Included articles contain information about using Octenisept in endodontic practice and its properties. The publication date criterion was selected from January 2007 to August 2021. 52 articles were viewed during the review. After analyzing the literature for inclusion criteria, the total number of publications has become 10. According to literature data, the using of Octenisept for endodontic treatment is good alternative to other irrigants due to the antibacterial effects and clinical results © 2022, Journal of International Dental and Medical Research.All Rights Reserved.