There are interactions between the oral fluid and blood, showing the status of the hematosalivary barrier, which is a kind of non-specific adaptive mechanism. The purpose of this work is to assess the correlation between the biochemical parameters of the oral fluid and blood of patients after the office teeth whitening procedure. This study involved 81 patients aged 21 to 35 years, whose teeth color corresponded to A2 and darker on the Vita Classic scale. Depending on the teeth whitening technique used, the patients were divided into 2 groups. Oral fluid and blood were collected before whitening, immediately after, and 14 days later. The analysis of the data obtained showed that no statistically significant correlations were observed. Mathematical analysis showed the relationship of body fluids necessary to maintain the homeostasis of the body as a whole. The study of correlations after teeth whitening did not reveal statistically significant changes. The office teeth whitening procedure does not affect the blood parameters of patients, which indicates the safety of this intervention. © 2022 Authors. All rights reserved.