7-Methylguanine Inhibits Colon Cancer Growthin Vivo

7-Methylguanine (7-MG) is a natural inhibitor of poly(ADP-ribose) polymerase 1 and tRNA-guanine transglycosylase, the enzymatic activity of which is central for the proliferation of cancer cells. Recently, a number of preclinical tests have demonstrated the safety of 7-MG and a regimen of intragastric administration was established in mice. In the present work, the pharmacological activity of 7-MG was studied in BALB/c and BALB/c nude mice with transplanted tumors. It was found that 7-MG effectively penetrates tumor tissue and suppresses colon adenocarcinoma growth in the Akatol model, as well as in a xenograft model with human HCT116 cells.

Авторы
Kirsanov K.I.1, 2 , Fetisov T.I.1 , Antoshina E.E.1 , Gor’kova T.G.1 , Trukhanova L.S.1 , Shram S.I.3 , Nagaev I.Yu.3 , Zolotarev Yu.A.3 , Abo Qoura L.1, 2 , Pokrovsky V.S. 1, 2 , Yakubovskaya M.G.1 , Švedas V.K.4, 5 , Nilov D.K.4
Издательство
Общество с ограниченной ответственностью «АКТА НАТУРЭ»
Номер выпуска
2
Язык
Английский
Страницы
50-52
Статус
Опубликовано
Подразделение
Кафедра биохимии имени академика Т.Т. Березова
Номер
16
Том
16
Год
2024
Организации
  • 1 Blokhin National Medical Research Center of Oncology, Institute of Carcinogenesis
  • 2 RUDN University, Medical Institute
  • 3 National Research Centre “Kurchatov Institute
  • 4 Lomonosov Moscow State University, Belozersky Institute of Physicochemical Biolog
  • 5 Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatic
Ключевые слова
7-methylguanine; inhibitor; poly(ADP-ribose) polymerase 1; tRNA-guanine transglycosylase; co-lon cancer; BALB/c mice
Дата создания
05.11.2024
Дата изменения
05.11.2024
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/157703/
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Analytical Chemistry. American Chemical Society. Том 96. 2024. С. 17432-17443