In the article, the authors analyze the range of problems associated with the consequences of the spread of coronavirus infection, making the study focus on resolving socio-economic issues in the context of ensuring political stability. The urgency of the study is determined by the presence (absence) of the effectiveness of the functioning of information and communication channels in the social sphere, concerning messages about public health, prevention of outbreaks of epidemics and pandemics. Recommendations of a socio-political nature to mitigate the identified negative consequences of the COVID-19 pandemic, based on the regional characteristics of the constituent entities of the Russian Federation are in demand. The impact of the pandemic on the world economy, regional partnerships, socio-economic factors of human existence is noted. It is shown that different states solve the problems of fighting the virus in different ways. The authors believe that when solving state problems of minimizing the socio-economic consequences of the spread of COVID-19 in the context of ensuring political stability, an integrated interdisciplinary approach is required. It has been demonstrated that it is quite difficult for governments to assess the effects and find effective answers to solving the problem of minimizing the consequences of the spread of a pandemic coronavirus infection because of its scale. Some directions of reducing the negative socio-economic consequences of the spread of COVID-19 are given, taking into account provision of political stability. The authors complement the existing study approaches to solving the problem of reducing the degree of negative factors affecting the deterioration of the socio-economic situation in communities.