Pharmacology of a new medicinal form, phenasal granules

Experiments on mice and rats were made to study a new medicinal form, phenasal granules given per os and to compare it with ground tablets and powder of phenasal as regards the intestinal content, absorption capacity, anthelminthic activity and toxicity. The intestinal content and absorption capacity of phenasal were medicinal form-dependent. The highest anthelminthic activity was exhibited by phenasal granules. Acute toxicity of powder, ground tablets and granules of phenasal administered to mice and rats per os remained the same.

Авторы
Zolotukhin S.I.1 , Vinogradova L.F. 1 , Kozlova L.M.1
Редакторы
-
Издательство
-
Номер выпуска
2
Язык
Русский
Страницы
88-91
Статус
Опубликовано
Подразделение
-
DOI
-
Номер
-
Том
46
Год
1983
Организации
  • 1 Univ. Druzhby Narodov, Moscow
Ключевые слова
new drug; niclosamide; niclosamide; animal experiment; drug formulation; helminthiasis; intoxication; mouse; nematode; nonhuman; pharmacology; rat; toxicity; absorption; animal; article; cestodiasis; comparative study; dose response; drug screening; intestine; male; metabolism; powder; tablet; Animalia; Absorption; Animal; Comparative Study; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; English Abstract; Hymenolepiasis; Intestines; Male; Mice; Niclosamide; Powders; Rats; Tablets
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/1428/