Review. L-lysine alpha-oxidase: Physicochemical and biological properties

This review summarizes data on the properties of L-lysine alpha-oxidase, an enzyme that belongs to the group of oxidases of L-amino acids. This enzyme acts virtually only on L-lysine with a rather low Km yielding alpha-keto-epsilon-aminocaproic acid. The decrease in the level of the essential amino acid L-lysine and the formation of hydrogen peroxide during the reaction possibly provide the basis for the unique properties of L-lysine alpha-oxidase: cytotoxic, antitumor, antimetastatic, anti-invasive, antibacterial, and antiviral activities, as well as an immunomodulating effect. Native L-lysine alpha-oxidase and its immobilized forms are promising tools for determination of concentration of L-lysine in various biological materials.

Авторы
Редакторы
-
Журнал
Издательство
-
Номер выпуска
10
Язык
Русский
Страницы
1394-1402
Статус
Опубликовано
Подразделение
-
DOI
-
Номер
-
Том
67
Год
2002
Организации
  • 1 Russian Peoples' Friendship Univ., ul. Miklukho-Maklaya 8, Moscow, 117198, Russian Federation
Ключевые слова
Anti-invasive effect; Antibacterial enzyme; Antimetastatic effect; Antitumor enzyme; Antiviral enzyme; Enzymes in medicine; Immobilized enzymes; L-amino acid oxidase; L-lysine alpha-oxidase; L-lysine assay
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/132/