Парентеральная литолитическая терапия уратного уролитиаза

Parenteral litholytic therapy of urate urolithiasis

We studied clinical efficacy of parenteral dissolving of urate concrements with trometamol N monotherapy. Parenteral litholytic therapy of urate uroliths was conducted in 8 (16.4%) patients with renal and 41 (83.6%) patients with ureteral concrements. The solution was performed with trometamol N (Berlin Chemie, Germany). Stimulation of the drug elimination by the affected kidney was provided by renal parenchyma exposure to low-intensive laser irradiation. For assessment of the dynamics of renal function recovery and urine passage along the upper urinary tract in the presence of ureteral concrement we used deep radiothermometry and dopplerography. The concrements solved completely in 36 (73.5%) patients, small fragments less than 0.4 cm in size evacuated spontaneously after partial dissolution. Mean duration of litholysis was 6.3 ± 2.2 days.