Transient subendocardial ischemia in nifedipine abolition of hypertensive crises

Sublingual nifedipine, 30 mg, was used to abolish hypertensive crises in 32 patients. A follow-up of changes in blood pressure, ECG, and echocardiographic parameters evaluating the cardiac performance and central hemodynamics was performed during 4 hours after the drug. The patients with profound myocardial hypertrophy and dilatation at a left ventricular myocardial weight of over 200 g at the peak of the antihypertensive effect occurred for 15-60 min exhibited transient ECG changes by the type of subendocardial ischemia despite an above 25% reduction in mean blood pressure and the lack of severe reflex tachycardia, the pump function of the heart showing no decreases. The ejection fraction increased from 51.0 ± 2.8 to 62.0 ± 2.5% (p < 0.05) due to lower afterload. There were no clinical manifestations typical of myocardial ischemia.

Авторы
Ivleva Ya.A. , Kobalava Zh.D. , Demidenko I.V.1 , Krasnobaeva G.M.1 , Strugovshchikov A.N.1 , Moiseev V.S. 1
Редакторы
-
Журнал
Издательство
KlinMed Consulting
Номер выпуска
11
Язык
Русский
Страницы
21-23
Статус
Опубликовано
Подразделение
-
DOI
-
Номер
-
Том
31
Год
1991
Организации
  • 1 Kafedra Vnutrennikh Boleznej Universiteta Druzhby Narodov, Moskva, Russia
Ключевые слова
nifedipine; nifedipine; article; blood pressure; clinical article; echocardiography; human; hypertension; leg; sublingual drug administration; adult; aged; cardiomegaly; coronary artery disease; drug effect; electrocardiography; female; hemodynamics; hypertension; iatrogenic disease; male; pathophysiology; Adult; Aged; Blood Pressure; Cardiomegaly; Coronary Disease; Echocardiography; Electrocardiography; English Abstract; Female; Hemodynamics; Human; Hypertension; Male; Middle Age; Nifedipine
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/1111/