We prospectively evaluated the efficiency of chronic cystitis therapy in women with 0.1% sodium hyaluronate (Uro-hyal) on the basis of regression of leukocyturia, erythrocyturia, bacteriuria, subjective sensations (according to the QoL scale). We also observed all the patients during 12 months after treatment and recorded the number of recurrences. As a result, we recorded a significant improvement in the quality of life and by 2.5 times decrease in recurrences of the disease after Uro-hyal therapy compared to the control group. Conclusions. The intravesical use of 0.1% sodium hyaluronate contributes to restoring the protective properties of the mucous membrane of the bladder and maintains a long time without recurrence of the disease.