Valproate-Induced Metabolic Syndrome

Valproic acid (VPA) and its salts (sodium calcium magnesium and orotic) are psychotropic drugs that are widely used in neurology and psychiatry. The long-term use of VPA increases the risk of developing adverse drug reactions (ADRs), among which metabolic syndrome (MetS) plays a special role. MetS belongs to a cluster of metabolic conditions such as abdominal obesity, high blood pressure, high blood glucose, high serum triglycerides, and low serum high-density lipoprotein. Valproate-induced MetS (VPA-MetS) is a common ADR that needs an updated multidisciplinary approach to its prevention and diagnosis. In this review, we consider the results of studies of blood (serum and plasma) and the urinary biomarkers of VPA-MetS. These metabolic biomarkers may provide the key to the development of a new multidisciplinary personalized strategy for the prevention and diagnosis of VPA-MetS in patients with neurological diseases, psychiatric disorders, and addiction diseases.

Authors
Shnayder Natalia A.1, 2 , Grechkina Violetta V.1 , Trefilova Vera V.1, 3 , Efremov Ilya S.4 , Dontceva Evgenia A.2, 5 , Narodova Ekaterina A.2 , Petrova Marina M.2 , Soloveva Irina A.2 , Tepnadze Liia E.2 , Reznichenko Polina A.2 , Al-Zamil Mustafa 6 , Altynbekova Gulnara I.7 , Strelnik Anna I.8 , Nasyrova Regina F.1, 8
Journal
Biomedicines
Publisher
MDPI AG
Number of issue
5
Language
English
Pages
1499
Status
Published
DOI
10.3390/biomedicines11051499
Volume
11
Year
2023
Organizations
  • 1 Institute of Personalized Psychiatry and Neurology, Shared Core Facilities, V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology, 192019 Saint Petersburg, Russia
  • 2 Shared Core Facilities “Molecular and Cell Technologies”, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia
  • 3 Department of Neurology, Hospital for War Veterans, 193079 Saint Petersburg, Russia
  • 4 Department of Psychiatry and Narcology, Bashkir State Medical University, 450008 Ufa, Russia
  • 5 Federal Centre for Neurosurgery, 630087 Novosibirsk, Russia
  • 6 Department of Physiotherapy, Faculty of Continuing Medical Education, Peoples’ Friendship University of Russia, 117198 Moscow, Russia
  • 7 Department of Psychiatry and Narcology, S.D. Asfendiarov Kazakh National Medical University, Almaty 050022, Kazakhstan
  • 8 International Centre for Education and Research in Neuropsychiatry, Samara State Medical University, 443016 Samara, Russia
Keywords
valproic acid; metabolic syndrome; personalized approach; metabolomic; metabolome
Date of creation
16.11.2023
Date of change
16.11.2023
Short link
https://repository.rudn.ru/en/records/article/record/94477/
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