The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies

In recent times, there has been a significant increase in researchers’ interest in the functions of microRNAs and the role of these molecules in the pathogenesis of many multifactorial diseases. This is related to the diagnostic and prognostic potential of microRNA expression levels as well as the prospects of using it in personalized targeted therapy. This review of the literature analyzes existing scientific data on the involvement of microRNAs in the molecular and cellular mechanisms underlying the development of pathologies such as Alzheimer’s disease, cerebral ischemia and reperfusion injury, and dysfunction of the blood–brain barrier.

Authors
Tregub Pavel P. 1, 2, 3 , Ibrahimli Irada1 , Averchuk Anton S.3 , Salmina Alla B.3, 4 , Litvitskiy Peter F.1 , Manasova Zaripat Sh.1 , Popova Inga A.1
Publisher
MDPI AG
Number of issue
16
Language
English
Pages
12899
Status
Published
Department
scientific and educational resource center "Innovative technologies of immunophenotyping, digital spatial profiling and ultrastructural analysis"
Volume
24
Year
2023
Organizations
  • 1 Department of Pathophysiology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia
  • 2 Scientific and Educational Resource Center “Innovative Technologies of Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis”, RUDN University, 117198 Moscow, Russia
  • 3 Research Center of Neurology, 125367 Moscow, Russia
  • 4 Research Institute of Molecular Medicine and Pathobiochemistry, Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia
Keywords
miRNA; Alzheimer’s disease; ischemia–reperfusion injury; blood–brain barrier; RNA biology; neuroinflammation; oxidative stress
Date of creation
25.08.2023
Date of change
25.08.2023
Short link
https://repository.rudn.ru/en/records/article/record/94204/
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