This article is devoted to the description of the author's methodology of teaching business cross-cultural communication to students of non-linguistic universities, which is the basis for the development of the textbook “Business English”. Testing its results in the educational process allows to state a sufficiently high level of efficiency in mastering business foreign language and serving cross-cultural communication in the field of modern business. The methodology developed by the authors is based on a set of principles: the principle of strict selection of language tools and speech situations practiced in the modern business world; the communicative principle of teaching material with a wide variety of colloquial clichés used in the field of business communication based on the psychological and pedagogical approach in teaching languages; the principle of constructing semantically correct sentences in professional communication; the principle of a modular approach to the development of a coherent system of complete didactically and logically completed training modules; the principle of universality of educational levels, which allows using this textbook in the framework of educational undergraduate and graduate programs for students with various degrees of language training to develop basic competence of generating foreign language expressions in situations of business communication.