HETEROCYCLIC CARBONITRILE CARBOXAMIDES AS A NEW CYTOSTATIC

The reaction of Pyruvic acid with 1,1,2,2-Tetracarbonitrilethane was the first to synthesize the corresponding Tricarboxamido derivative. The cyclization product of the intermediate -2-amino-5-methyl-3,4-dicyano-4,5-dihydrofuran-4,5-dicarboxamide was isolated. Their possibilities of "landing" on a promising nanocarrier - nanodiamonds, as well as cytostatic properties were studied.

Authors
Nasakin O.E.1 , Pavlov V.N. 2 , Khrustalev V.N. 3 , Eremkin A.V.1 , Lyalin G.S.1
Conference proceedings
СОВРЕМЕННЫЕ ПРОБЛЕМЫ ХИМИИ, ТЕХНОЛОГИИ И ФАРМАЦИИ
Publisher
Чувашский государственный университет имени И.Н. Ульянова
Language
English
Pages
151-154
Status
Published
Year
2020
Organizations
  • 1 FSBEI HE "Chuvash State University named after IN Ulyanov"
  • 2 University of Barcelona
  • 3 Peoples ' friendship University of Russia
Keywords
2-Tetracarbonitrilethane; 2-Amino-5-methyl-3; 4-dicyano-4; 5 dihydrofuran-4; 5-dicarboxamide; nanodiamonds; cytostatic activity
Date of creation
06.07.2022
Date of change
06.07.2022
Short link
https://repository.rudn.ru/en/records/article/record/89452/
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SYNTHESIS OF 3-AMINOMETHYL-5-ARYLISOXAZOLES

Article
Kolesnik I.A., Petkevich S.K., Potkin V.I., Mertsalov D.F., Nadirova M.A., Sokolova J.S., Chervyakova L.V.
СОВРЕМЕННЫЕ ПРОБЛЕМЫ ХИМИИ, ТЕХНОЛОГИИ И ФАРМАЦИИ. Чувашский государственный университет имени И.Н. Ульянова. 2020. P. 130-132