Analysis of the effectiveness of antiretroviral therapy in patients in intensive care unit [Анализ эффективности антиретровирусной терапии у больных отделения интенсивной терапии]

The article presents the results of the analysis of the effectiveness of antiretroviral therapy in patients of the intensive care unit (ICU) for HIV-infected patients, created on the basis of the Infectious Diseases Clinical Hospital No. 2 in Moscow. The aim: to study the effectiveness of ART in HIV-infected patients admitted to the intensive care unit of an infectious hospital (ICU). Method and materials. Clinical and epidemiological data of 169 HIV patients admitted to the ICU were analyzed. Patients were divided into 2 groups: 103 patients in the first group already initiated antiretroviral therapy (ART) before hospitalization, while 66 naïve patients in the second initiated during hospitalization. Clinical improvement in the ICU and transfer to continued care on general wards implied clinical effectiveness of treatment. The “laboratory” effectiveness was evaluated on the basis of the results of molecular biological and immunological studies. Results. Two NRTIs plus PI were the most used regimen in the groups (51.6% in group 1, 83.3% in group 2). Cytomegalovirus (CMV) emerged as the most common opportunistic (30.1% in group 1, 62.12% in group 2). Immunological and virologic status of the studied groups were as follow: 889 166±213 484 HIV-1 RNA copies/mL in group 1 and 481 075±179 810 HIV-1 RNA copies/mL in group 1; CD4+ 171.72±22.74 cells/mm3 in group 1 and 98.18±17.26 cells/mm3 in group 2. Patient survival rate was 19.42% in the group 1 and 31.82% in the group 2. Patients in the group 1 receiving 2 NRTIs in combination with Atazanavir had a good clinical outcome (p<0.01). 26% patients in the first group had undetectable HIV RNA levels, 25% in the same group had detected levels between 20-1000 copies/ml. 91% patients in group 2 had exceeding levels of HIV viral load which correlates with the natural course of the disease. Zero CD4-cell counts were recorded 5.7 times more in the group 2. Conclusion. Our study demonstrates a significant difference between the viral load indicators in the comparison groups. The immunological characteristics also had significant differences. A poor clinical efficacy of ART is attributed to late initiation and short duration due to disease severity which lead to deaths in infected patients. © 2021 Infectious Diseases: News, Opinions, Training. All rights reserved.

Voznesenskiy S.L. 1 , Petrova E.V. 2 , Kozhevnikova G.M. 1 , Ermak T.N. 3 , Kravchenko A.V. 3 , Klimkova P.V.2 , Tishakova D.A.2
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  • 1 People's Friendship University of Russia (RUDN University), Moscow, 117198, Russian Federation
  • 2 Infectious Diseases Clinical Hospital No 2, Moscow, 105275, Russian Federation
  • 3 Central Research Institute of Epidemiology, The Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, 111123, Russian Federation
Antiretroviral therapy; HIV-infection; Intensive care unit
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