Background: This study aimed at finding the diagnostic and prognostic possibilities of determining apoC-II, as a serological marker for MM in early gestation. Methods and Results: The study included 182 pregnant women aged between 18 and 45 years at gestational age under 11 weeks. All women were divided into 3 groups. Group 1 included 90 women with MM; Group 2 included 52 women with spontaneous miscarriage; Group 3 included 40 women without pathology (control group). Lipid metabolism disorders were diagnosed according to the Russian national recommendations of the VII revision (the Russian Society of Cardiologists [RSC, 2020]), considering the European recommendations (2019). Proteomic analysis of the blood serum was performed using liquid chromatography-mass spectrometry. Abnormalities in the lipid profile, manifested as isolated hypercholesterolemia, and combined hypercholesterolemia with hypertriglyceridemia, were more common in patients with MM and spontaneous abortions: 62.2% and 59.7% of cases, respectively, which correlates with the identified marker apoC-II in Group 1 and Group 2. Conclusion: ApoC-II can be considered as the most promising serologic marker for MM in the early gestation period for women with dyslipidemia. © 2021, International Medical Research and Development Corporation. All rights reserved.