The role of placental proteins in pregnant women during preparation for childbirth

The aim of the study was to determine the role of placental proteins (TBG, glycodelin and PAMG) in the process of cervical ripening before term delivery. Material and methods. A total of 245 pregnant women were examined at 38 — 39 weeks, including 65 with a «mature» cervix (group 1), 84 with an «insufficiently mature» cervix (group 2) and 96 women with an «immature» cervix (group 3). Pregnant women of the second and third groups were examined twice in the dynamics during one week. The material for the study was peripheral venous blood, in the serum of which the concentration of TBG was determined by the method of double immunodiffusion using a standard test system, PAMG and glycodelin were examined by the method of enzyme-linked immunosorbent assay. Results. There are high levels of TBG with unchanged PAMG and glycodelin levels in the peripheral blood of primiparous women with an «immature» cervix at full-term pregnancy. The in-creased content of TBG in the mother’s blood persists, the concentration of glycodelin increases, the level of PAMG does not change in the absence of the effect of preparing the organism for childbirth; when the cervix matures, the level of TBG decreases. Conclusion. TBG is probably involved in the pathogenesis of cervical remodeling; the role of glycodelin and PAMG has not been determined. The decrease in TBG in women with full-term pregnancy can be used as a criterion for the effectiveness of preparing the organism for child-birth. © 2022, Media Sphera Publishing Group. All rights reserved.