Mesenchymal stromal cell therapy alone does not lead to complete restoration of skin parameters in diabetic foot patients within a 3-year follow-up period

Introduction: Mesenchymal stromal cells (MSCs) administration is an effective option for the treatment of diabetic foot ulcers (DFUs). However, to date, studies assessing long-term outcomes and evaluating skin parameters after cell-based therapy are lacking. We presented the clinical outcomes of 3 patients, treated for DFUs with the bone marrow MSCs 3 years earlier. Methods: Ultrasound examination was used to compare collagen density and epidermal thickness in areas of healed ulcers in comparison with non-affected skin used as a control. Ultrasound and dermatoscopy were used to exclude neoplasm formation, to assess scar contracture and wound recurrence. Results: In all patients, no ulcer recurrence was detected, which was lower than the expected 60% rate of re-ulceration in diabetic patients in a 3-year period (OD [odds ratio] = 0.095, P = 0.12). No neoplasm formation, no contracture of hypertrophic scar, and adjacent tissue were registered. Collagen ultrasound density was decreased by 57% (P = 0.053) and epidermal thickness was increased by 72% (P = 0.01) in the area of healed ulcers in all patients. Conclusion: MSCs therapy alone did not result in the complete restoration of the skin parameters within a 3-year period. MSCs may represent important adjuvant to the therapy, however, other novel approaches are required to achieve better results. © 2022 The Author(s).

Authors
Maksimova N.V.1 , Michenko A.V.2 , Krasilnikova O.A.3 , Klabukov I.D. 3 , Gadaev I.Yu.4 , Krasheninnikov M.E. 5 , Belkov P.A.6 , Lyundup A.V. 5
Journal
Publisher
Tabriz University of Medical Sciences
Number of issue
1
Language
English
Pages
51-55
Status
Published
Volume
12
Year
2022
Organizations
  • 1 Department of Endocrinology, Sechenov First Moscow State Medical University (Sechenov University), Russian Federation
  • 2 Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology, Moscow, Russian Federation
  • 3 Department of Regenerative Technologies and Biofabrication, National Medical Research Radiological Center, Obninsk, Russian Federation
  • 4 Hospital Therapy №1, Sechenov First Moscow State Medical University (Sechenov University), Russian Federation
  • 5 Research and Educational Resource Center for Cellular Technologies, Peoples’ Friendship University of Russia, Moscow, Russian Federation
  • 6 Company ANTA-Med, Moscow, Russian Federation
Keywords
Cell therapy; Diabetic foot ulcer; Mesenchymal stem cells; Mesenchymal stromal cells; Regenerative medicine; Wound healing
Date of creation
06.07.2022
Date of change
06.07.2022
Short link
https://repository.rudn.ru/en/records/article/record/84193/
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