The Use of Several Polymers in the Composition of Eye Drops to Improve their Rheological Properties

The physical and chemical properties (viscosity, pH measurement, calculation of osmolarity values) of polymeric solutions were studied. Such solutions are proposed to be included in the composition of eye drops to improve their rheological properties: as a solution of polyethylene glycol 6000 (PEG-6000), polyethylene glycol 4000 (PEG-4000), methylcellulose (MC), carboxymethyl cellulose (Na-CMC), Hydroxybromoyl methylcellulose (HPMC), hydroxyethylcellulose (HEC), collidone-25, dextrin, and microcrystalline cellulose). It was found that all polymers have different biological, physical, and chemical properties at different concentrations. Depending on the requirements for specific eye drops, polymeric solutions such as HPMC D 4000 H 2208 (0.4%) solution (pH 7.02; viscosity 12.74 mm2/s), HEC 250 НХ (0.3%) (pH 7.0; viscosity 14.03 mm2/s), HEC 250 НХ (0.3%) (pH 7.0; viscosity 14.03 mm2/s) and PEG-6000 PLURACARE (15%) (pH 7.03; viscosity 1488 mm2/s) can be used as adjuvants to increase and prolong the effect of the efficacy of eye drops, since their pH value is closest to the human eye. © 2022, Dr. Yashwant Research Labs Pvt. Ltd.. All rights reserved.