Green synthesis of polysubstituted pyrroles through a domino sequence of aza-Claisen rearrangement/nucleophilic addition/oxidation/acylation

A pseudo three-component reaction of 2-imidazolines with electron-deficient alkynes furnishes 1,2,2,3-tetrasubstituted imidazolidines containing N-vinylpropargylamine moiety. Heating imidazolidines in aerobic conditions in butyl acetate solution leads to highly functionalized pyrroles through aza-Claisen rearrangement/nucleophilic addition/oxidation/acylation. © 2022 Author(s).

Authors
Golubenkova A.S. 1 , Golantsov N.E. 1 , Varlamov A.V. 1 , Voskressensky L.G. 1
Conference proceedings
AIP Conference Proceedings
Language
English
Status
Published
DOI
10.1063/5.0069005
Number
020019
Volume
2390
Year
2022
Organizations
  • 1 Organic Chemistry Department, Peoples' Friendship University of Russia, RUDN University, 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation
Date of creation
06.07.2022
Date of change
06.07.2022
Short link
https://repository.rudn.ru/en/records/article/record/83852/
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