Visible-Light-Driven Palladium-Catalyzed Radical Tandem Dearomatization of Indoles with Unactivated Alkenes

A mild visible-light-driven palladium-catalyzed radical tandem dearomatization of indoles with unactivated alkenes is described with moderate to good yields and good to excellent diastereoselectivities. Under visible-light irradiation, the photoexcited state of the palladium complex was formed, which could transfer a single electron to N-(2-bromobenzoyl)indoles, leading to a hybrid palladium radical chemistry. This provides efficient and atom-economical access to diverse 2,3-disubstituted indoline derivatives. © 2022 American Chemical Society

Authors
Chen S. 1 , Van Meervelt L. , Van Der Eycken E.V. , Sharma U.K.1
Journal
Organic Letters
Number of issue
5
Language
English
Pages
1213-1218
Status
Published
Link
External link
DOI
10.1021/acs.orglett.1c04390
Volume
24
Year
2022
Organizations
  • 1 Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, KU Leuven, Celestijnenlaan 200F, Leuven, B-3001, Belgium
  • 2 Biomolecular Architecture, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, Leuven, B-3001, Belgium
  • 3 People’s Friendship University of Russia (RUDN University), Miklukho-Maklaya Street 6, Moscow, RU-117198, Russian Federation
Date of creation
06.07.2022
Date of change
06.07.2022
Short link
https://repository.rudn.ru/en/records/article/record/83845/
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