Molecular Catalysis.
Elsevier B.V..
Vol. 522.
2022.
The development atom-economic strategies to construct structurally diverse isoquinolones remains challenging. Herein, we disclose a practical Pd-catalyzed cyclization/base-promoted aromatization/ring-opening protocol of N-propargyl-1,3-oxazolidines with carboxylic acids. In the current domino reaction, a series of ester-functionalized isoquinolones is obtained in moderate to good yields via C−O bond cleavage, which features a broad functional group tolerance. © 2022 Elsevier B.V.