New Synthesis of Tetrahydroisoquinolines

Abstract: The reaction of cyclohexylidenecyanothioacetamide with N,N-dimethylformamide dimethyl acetal was studied. This transformation, depending on the reaction conditions, leads to different results: when the starting reagents are refluxed without a solvent, 3-(methylsulfanyl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile is formed, and refluxing in benzene leads to 2-cyano-3-(dimethylamino)prop-2-enethioamide. The structure of these products was studied by XRD analysts. © 2022, Pleiades Publishing, Ltd.

Authors
Dyachenko I.V.1 , Dyachenko V.D.1 , Dorovatovskii P.V. 2 , Khrustalev V.N. 3, 4 , Nenajdenko V.G. 5
Number of issue
5
Language
English
Pages
657-662
Status
Published
Volume
58
Year
2022
Organizations
  • 1 Lugansk State Pedagogical University, Lugansk, 91011, Ukraine
  • 2 Kurchatov Institute National Research Center, Moscow, 123182, Russian Federation
  • 3 Peoples’ Friendship University of Russia (RUDN University), Moscow, 117198, Russian Federation
  • 4 Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russian Federation
  • 5 Lomonosov Moscow State University, Moscow, 119991, Russian Federation
Keywords
N,N-dimethylformamide dimethyl acetal; tetrahydroisoquinoline; thioamide; XRD analysis
Date of creation
06.07.2022
Date of change
06.07.2022
Short link
https://repository.rudn.ru/en/records/article/record/83623/
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