Aim. To study the possibilities of using multi-channel volume sphygmography (MCVS) in prophylactic medical examination of the population. Material and methods. Simultaneous examination of 522 individuals older than 18 years was performed. Along with standard procedures provided by the prophylactic medical examination program synchronous registration of blood pressure (BP) on four extremities by MCVS was performed. At that a difference in systolic BP between arms (Delta SBParm) and legs (Delta SBPleg) and ankle-brachial index (ABI) were automatically calculated. Values of vertical bar Delta SBParm vertical bar or vertical bar Delta SBPleg vertical bar >= 15 mm Hg or ABI <= 0.9 were considered as markers of atherosclerotic vascular disease. Results. Signs of peripheral arterial atherosclerotic lesions among patients >= 40 years old were found in 14.7% of the cases (95% confidence interval [CI] 11.7-18.4). Relative risks of atherosclerotic lesions in arteries increase 1.71-fold (95% CI 1.06-2.74) in arterial hypertension, 1.70-fold (95% CI 1.08-2.68) - in obesity, 1.91 fold (95% CI 1.17-3.12) - in diabetes, as well as with the increasing levels of cardiovascular risk. In patients with ischemic heart disease and a history of cerebral stroke MCVS can detect signs of multifocal atherosclerosis in 21% (95% CI 14-32) and 22% (95% CI 9-46) of the cases, respectively. Conclusion. MCVS with the determination of Delta SBParm, Delta SBPleg and ABI may be regarded as the basis for low-cost and efficient system of cardioangiological screening.