DNA microcircles - The promising tool for in vivo studies of the behavior of non-canonical DNA

The paper discusses the reasons for the resurrection of the term DNA microcircles through the change of its definition to “topologically closed DNA circles with the length less than 1 Kbp” from the entire population of circular DNA that holds the name of minicircles. The possible applications of such tool for in vivo studies of non-canonical DNA are also discussed. Prospective for in vivo and in vitro studies of non-canonical DNA cloned into microcircles are demonstrated. A method of stepwise elongation or shortening of plasmids is discussed. © 2022 Elsevier Ltd

Authors
Vetcher A.A. 1, 2 , Stanishevskiy Y.M. 1
Journal
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
Publisher
Elsevier
Language
English
Pages
84-88
Status
Published
DOI
10.1016/j.pbiomolbio.2022.02.002
Volume
169-179
Year
2022
Organizations
  • 1 Peoples’ Friendship University of Russia
  • 2 Complementary and Integrative Health Clinic of Dr. Shishonin
Keywords
Microcircles; Minicircles; Non-B-DNA structures; Non-canonical DNA
Date of creation
29.04.2022
Date of change
12.07.2023
Short link
https://repository.rudn.ru/en/records/article/record/82921/
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