Наследие веков.
Южный филиал Федерального государственного бюджетного научно-исследовательского учреждения "Российский научно-исследовательский институт культурного и природного наследия им. Д.С. Лихачева".
2021.
P. 93-99
Novel tetrazole PtIIand PdIIcomplexes with enhanced water solubility: Synthesis, structural characterization and evaluation of antiproliferative activity
Novel platinum(II) and palladium(II) chlorido complexes with tetrazole derivatives 1-(2-hydroxyethyl)tetrazole (het) and 1-[tris(hydroxymethyl)methyl]tetrazole (thm), viz. cis-[Pt(het)2Cl2], trans-[Pt(het)2Cl2], trans-[Pt(thm)2Cl2], trans-[Pd(het)2Cl2], and trans-[Pd(thm)2Cl2], were synthesized. The compounds were characterized by elemental and high-resolution electrospray ionization (HRESI) mass spectrometry, high-performance liquid chromatography (HPLC), 1H, 13C and 195Pt nuclear magnetic resonance (NMR) spectroscopy, thermal analyses, and Infrared (IR) spectroscopy. Molecular and crystal structures of trans-[PdL2Cl2] and trans-[PtL2Cl2] (L = het, thm) were established by single-crystal X-ray analysis. The complex cis-[Pt(het)2Cl2] was found to undergo cis-to-trans isomerization upon heating in acetonitrile solution and in the solid state. The synthesized complexes show rather high water solubility lying in the range of 2-10 mg/L.
Authors
Serebryanskaya T.V.1
,
Lyakhov A.S.1
,
Ivashkevich L.S.1
,
Grigoriev Y.V.1
,
Ivashkevich O.A.1
,
Kritchenkov A.S.
2
,
Khrustalev V.N.
2
,
Tskhovrebov A.G.
2,
3
Publisher
Walter de Gruyter GmbH
Number of issue
1-2
Language
English
Pages
23-32
Status
Published
Volume
236
Year
2021
Organizations
- 1 Belarusian State University
- 2 Peoples' Friendship University of Russia
- 3 N. N. Semenov Federal Research Center for Chemical Physics|Russian Academy of Sciences
Keywords
antiproliferative activity; cis/trans isomerism; Palladium(II); Platinum(II); tetrazoles
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Zeitschrift fur Kristallographie - Crystalline Materials.
Walter de Gruyter GmbH.
Vol. 236.
2021.
P. 117-122