Contemporary patterns of presentation, diagnostics and management of upper tract urothelial cancer in 101 centres: the Clinical Research Office of the Endourological Society Global upper tract urothelial carcinoma registry

PURPOSE OF REVIEW: To assess patterns of presentation, diagnostics and treatment in patients with upper tract urothelial carcinoma (UTUC), a multicentre registry was launched. Clinical data of UTUC patients were prospectively collected over a 5-year period. RECENT FINDINGS: Data from 2380 patients were included from 2014 to 2019 (101 centres in 29 countries). Patients were predominantly male (70.5%) and 53.3% were past or present smokers. The majority of patients (58.1%) were evaluated because of symptoms, mainly macroscopic hematuria. Computed tomography (CT) was the most common performed imaging modality (90.5%). A ureteroscopy (URS) was part of the diagnostic process in 1184 (49.7%) patients and 488 (20.5%) patients were treated endoscopically. In total, 1430 patients (60.1%) were treated by a radical nephroureterectomy, 59% without a prior diagnostic URS. Eighty-two patients (3.4%) underwent a segmental resection, 19 patients (0.8%) were treated by a percutaneous tumour resection. SUMMARY: Our data is in line with the known epidemiologic characteristics of UTUC. CT imaging is the preferred imaging modality as also recommended by guidelines. Diagnostic URS gained a stronger position, however, in almost half of patients a definitive treatment decision was made without complete endoscopic information. Only one-third of patients with UTUC are currently treated with kidney sparing surgery.

Authors
Baard J.1 , Cormio L.2 , Cavadas V. 3 , Alcaraz A.4 , Shariat S.F. 3, 5, 6, 7 , De la Rosette J.8 , Laguna M.P.8
Publisher
Lippincott Williams & Wilkins
Number of issue
4
Language
English
Pages
354-362
Status
Published
Volume
31
Year
2021
Organizations
  • 1 Department of Urology|University of Amsterdam
  • 2 Department of Urology|University of Foggia
  • 3 Department of Urology
  • 4 Department of Urology Hospital Clinic i Provincial de Barcelona
  • 5 Department of Urology|Medical University of Vienna
  • 6 Department of Urology|Motol Hospital Charles University
  • 7 Department of Urology|I.M. Sechenov University
  • 8 Department of Urology|Medipol Mega University Hospital|Istanbul Medipol University
Date of creation
16.12.2021
Date of change
16.12.2021
Short link
https://repository.rudn.ru/en/records/article/record/80385/
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