Correctional abilities of regular muscle activity in relation to erythrocytes' microrheological features of rats with experimentally developed hypertension

Difficulties in the early stage detection of erythrocytes' microrheological abnormalities during the development of hypertension are connected with falling out of clinicians' point of view of persons with first signs of this pathology. It dictates the necessity of experimental investigations on laboratory animals with just developed hypertension in them. Earlier at this pathology, it was observed the high efficiency of non-medication impacts in relation to the lowering of arterial pressure and weakening of thrombocyte and vascular dysfunctions. At the same time, there is still no clarity on the question about the impact of regular exercise on erythrocytes' microrheological features at the beginning of hypertension development. About 87 healthy male rats of Wistar line at the age of 2.5-3 months were taken into the investigation. Twenty-nine animals out of them had experienced no impacts and composed the control group. Fifty-eight rats had hypertension developed by prescribing them cardio angionefo pathogenic semisynthetic diet. Then these rats were casually divided into experimental (31 rats) group and control group (27 rats). Rats from the experimental group during 60 subsequent days experienced daily exercise on a horizontal treadmill. Various subjects like biochemical, hematological, and statistical methods were used for investigation. As the hypertension development, the rats turned out to have a stable developing increase of systolic and diastolic pressure. At regular exercise, on the treadmill, the rats were noted to have a gradual decrease of their values during 60 days of investigation to the level of the norm. During hypertension development lipids' peroxidation activated in rats' erythrocytes because of activity weakening of their antioxidant protection. On the background of muscle activity in rats with hypertension the content of lipids' peroxidation products in erythrocytes progressively decreased, and by the 60th day of the experiment, they reached the control level of healthy rats. At hypertension development in rats, a reliable decrease of erythrocytes-discocytes quantity in blood was found. It was accompanied by an increase of reversibly and irreversibly changed erythrocytes' quantity in examined animals' blood. Their values were returning to control the level of healthy rats during 60 days of regular muscle activity. At hypertension development in rats, a quick rise of erythrocytes' sum in aggregate was found, and the rise in these aggregates' quantity was due to the decrease of free erythrocytes' number. Their quantity returned to control values at the end of 60 days of exercise. During experimental hypertension modeling, we noticed very early in rats' blood decrease of erythrocytes-discocytes' quantity, the rise of their reversibly and irreversibly level varieties with the strengthening of their aggregative ability. It takes place in the background of the weakening of erythrocytes' antioxidant protection and activation of lipids' peroxidation in them. Regular lasting muscle activity can eliminate existing erythrocytes' microrheological features' abnormalities in rats with recently developed hypertension.