Actuality of Studying the Steroid Profile of Saliva in the Planning of Dental Implantation

The aim of this review is to analyze the value of determining saliva steroid profile for diagnosis of various conditions and diseases. Steroid hormones, due to their high lipophilicity, quite easily pass from the blood to the saliva. Saliva steroids can reflect the concentration in plasma of a free fraction of hormones, that is, non-conjugated with proteins. During a systematic review of the literature, publications were considered in the electronic databases Google Scholar and PubMed, the main concept of which was to study the steroid profile of saliva and its diagnostic significance. 56 publications were initially studied, of which 39 were included in the review after analysis by exclusion criteria. The study of saliva steroid profile is an appropriate technique, which can confirm some diagnoses, such as Cushing’s syndrome. At the same time, it is necessary to keep in mind the limitations imposed by the saliva itself as a biomatrix due to the variability of its composition and cross sensitivity of components to certain reagents. © 2021