A Three-Component Synthesis of 3-Functionally Substituted 5,6-Dihydropyrrolo[2,1-a]isoquinolines

Synthesis of novel C3-substituted 5,6-dihydropyrrolo[2,1-a]isoquinolines via a three-component domino reaction of 1-aroyl-3,4-dihydroisoquinolines, terminal alkynes and CH-acids under microwave irradiation in dry acetonitrile is described. The method developed enables the obtainment of highly functionalized compounds with pharmacophore groups, which are potentially biologically active. © 2021 Wiley-VHCA AG, Zurich, Switzerland

Authors
Miftyakhova A.R. 1 , Borisova T.N. 1 , Titov A.A. 1 , Sidakov M.B. 1 , Novikov R.A. 2 , Efimov I.V. 1 , Varlamov A.V. 1 , Voskressensky L.G. 1
Journal
Chemistry and Biodiversity
Publisher
Wiley-VCH Verlag
Language
English
Status
Published
Link
External link
DOI
10.1002/cbdv.202100584
Year
2021
Organizations
  • 1 Organic Chemistry Department, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation
  • 2 N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prosp., Moscow, 119991, Russian Federation
Keywords
CH-acids; domino reaction; pyrrolo[2,1-a]isoquinolines; terminal alkynes; three-component reactions
Date of creation
16.12.2021
Date of change
16.12.2021
Short link
https://repository.rudn.ru/en/records/article/record/76861/
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