International Journal of Trade and Global Markets.
Inderscience Publishers.
Vol. 14.
2021.
P. 548-558
A Three-Component Synthesis of 3-Functionally Substituted 5,6-Dihydropyrrolo[2,1-a]isoquinolines
Synthesis of novel C3-substituted 5,6-dihydropyrrolo[2,1-a]isoquinolines via a three-component domino reaction of 1-aroyl-3,4-dihydroisoquinolines, terminal alkynes and CH-acids under microwave irradiation in dry acetonitrile is described. The method developed enables the obtainment of highly functionalized compounds with pharmacophore groups, which are potentially biologically active. © 2021 Wiley-VHCA AG, Zurich, Switzerland
Authors
Miftyakhova A.R.
1
,
Borisova T.N.
1
,
Titov A.A.
1
,
Sidakov M.B.
1
,
Novikov R.A.
2
,
Efimov I.V.
1
,
Varlamov A.V.
1
,
Voskressensky L.G.
1
Journal
Publisher
Wiley-VCH Verlag
Language
English
Status
Published
Link
Year
2021
Organizations
- 1 Organic Chemistry Department, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation
- 2 N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prosp., Moscow, 119991, Russian Federation
Keywords
CH-acids; domino reaction; pyrrolo[2,1-a]isoquinolines; terminal alkynes; three-component reactions
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Strahlentherapie und Onkologie.
Springer Science and Business Media Deutschland GmbH.
2021.