The Role of Lipid Peroxidation Products and Antioxidant Enzymes in the Pathogenesis of Aseptic and Purulent Inflammation in Cats

Objective: The work aimed to determine the state of lipid peroxidation products and the activity of the antioxidant system in cats with aseptic inflammation and purulent-inflammatory processes of varying severity. Materials and Methods: The intensity of the process of lipid peroxidation- antioxidant system processes in blood plasma was evaluated using commercial kits. The level of diene conjugates (DC), the content of malondialdehyde (MDA), the level of medium-weight molecules were deter- mined from lipid peroxidation indices. The state of antioxidant protection was assessed by indi- cators of superoxide dismutase (SOD) activity, catalase (CT), ceruloplasmin (CP) concentration, glutathione peroxidase activity, glutathione reductase (GLR), and total antioxidant activity (AOA). Results: With aseptic inflammation in the blood of cats, a slow activation of peroxidation reactions occurred. The DC indicator increased by 1.4 times, the SOD level rose by 1.38 times, the amount of GLR by 1.04 times, and the activation of total AOA by 9.06. In sepsis, the values of DC, MDA, and medium-weight molecules increased by 4.4, 8.4, and 8.8 times, respectively. With abscesses in the blood of cats, an increase in CT, CP, and GLR is observed against a background of a decrease in glutathione peroxidase. With purulent wounds, the total AOA of plasma increases by 2.5 times; with abscesses, the total AOA increases by 1.9 times, and with sepsis, it decreases by 1.5 times. Conclusion: With surgical infections in cats, deep biochemical changes or irreversible biochemical changes (in sepsis) occur that indicate a significantly enhanced catabolic orientation of metabolic processes and the accumulation of toxic metabolites, which leads to damage and a decrease in tissue regenerative capacity. © The authors. Thisis an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0)

Authors
Rudenko P. 1, 2 , Vatnikov Y. 2 , Engashev S.3 , Kvochko A.4 , Notina E. 5 , Bykova I. 5 , Kulikov E. 2 , Rudenko A. 2 , Petrukhina O. 2 , Rudenko V.1
Publisher
Network for the Veterinarians of Bangladesh
Number of issue
2
Language
English
Pages
210-217
Status
Published
Volume
8
Year
2021
Organizations
  • 1 Biological Testing Laboratory, Branch of Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russian Federation
  • 2 Department of Veterinary Medicine, Peoples’ Friendship University of Russia, Moscow, Russian Federation
  • 3 Department of Parasitology and Veterinary and Sanitary Expertise, Moscow State Academy of Veterinary Medicine and Biotechnology, Moscow, Russian Federation
  • 4 Department of Physiology, Surgery and Obstetrics, Stavropol State Agrarian University, Stavropol, Russian Federation
  • 5 Deaprtment of Foreign Languages, Peoples’ Friendship University of Russia, Moscow, Russian Federation
Keywords
Antioxidants; cats; free radicals; inflammation; ovariohysterectomy; respiratory burst; surgical infection
Date of creation
16.12.2021
Date of change
16.12.2021
Short link
https://repository.rudn.ru/en/records/article/record/76788/
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