The relevance of the study included that scarcity of evidence about the burdens of diseases in Ethiopia, in particular to non-communicable diseases along with the impact of COVID-19. MATERIALS AND METHODS: The systematic analysis and content analysis using GBD 2019 database and health metrics datasets of 2020 was used to analyze diseases burdens trends of Ethiopia. The descriptive retrospective analysis has been performed, and reported in text and charts method. RESULTS: The result of the study showed increment of crude death and premature death due to both communicable and non-communicable diseases such as enteric infections, cardiovascular, neoplasm, others. CONCLUSION: COVID-19 would be the headache of Ethiopia health systems due to double burdens of diseases have steadily been shooting at ground. Hence, the nation should incite local based innovation work proactively and integrate all health services to fight with COVID-19 based on the experience of Russia.