Electrophilically activated nitroalkanes in double annulation of [1,2,4]triazolo[4,3-a]quinolines and 1,3,4-oxadiazole rings

Nitroalkanes activated with polyphosphoric acid could serve as efficient electrophiles in reactions with amines and hydrazines, enabling various cascade transformations toward heterocyclic systems. This strategy was developed for an innovative synthetic protocol employing simultaneous or sequential annulation of two different heterocyclic cores, affording [1,2,4]triazolo[4,3-a]quinolines with 1,3,4-oxadiazole substituents. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Authors
Aksenov A.V. 1 , Kirilov N.K.1 , Aksenov N.A. 1 , Aksenov D.A. 1 , Sorokina E.A. 2 , Lower C.3 , Rubin M. 1, 3
Journal
Molecules
Publisher
MDPI AG
Number of issue
18
Language
English
Status
Published
Link
External link
DOI
10.3390/molecules26185692
Number
5692
Volume
26
Year
2021
Organizations
  • 1 Department of Chemistry, North Caucasus Federal University, 1a Pushkin St, Stavropol, 355017, Russian Federation
  • 2 Organic Chemistry Department, Peoples’ Friendship, University of Russia (RUDN University), 6, Miklukho-Maklaya St, Moscow, 117198, Russian Federation
  • 3 Department of Chemistry, University of Kansas, 1567 Irving Hill Road, Lawrence, KS 66045, United States
Keywords
Annulation; Cascade transformations; Heterocycles; Nitroalkanes
Date of creation
16.12.2021
Date of change
16.12.2021
Short link
https://repository.rudn.ru/en/records/article/record/76647/
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