Chemistry of Functionalized Benzazepines. 5 [1]. Synthesis and Chemical Transformation of the 1,2,4,5-Tetrahydrospiro- [3H-2-benzazepine-3,1′-cycloalkanes]

The synthesis of new spire derivatives of tetrahydro-2-benzazepine was accomplished and their nitration, bromination, allylation, acetylation, formylation and oxidation reactions were studied. Nitration and bromination of 5-methyl(1,5-dimethyl)-1,2,4,5-tetrahydrospiro[3H-2-benzazepine-3,1′- cycloalkane] took place regioselectively on position C-8 of the phenyl ring. A nitrone was obtained for the first time in the title series. The structures of the compounds were established by ir and nmr spectroscopy.

Authors
Kouznetsov V.1 , Alirio Palma R. , Salas S.1 , Vargas L.Y.1 , Zubkov F. 2 , Varlamov A. 2 , Martfnez J.R.1
Journal
Journal of Heterocyclic Chemistry
Publisher
HeteroCorporation
Number of issue
5
Language
English
Pages
1591-1595
Status
Published
Link
External link
DOI
10.1002/jhet.5570340534
Volume
34
Year
1997
Organizations
  • 1 Lab. de Sintesis Organ. Fina, Escuela de Química, Universidad Industrial de Santander, A. A. 678, Bucaramanga, Colombia
  • 2 Department of Organic Chemistry, Druzhby Narodov University, Ordzhonikidze Street 3, Moscow, Russian Federation
Keywords
benzazepine derivative; cycloalkane derivative; acetylation; antiviral activity; article; central nervous system disease; depression; drug synthesis; drug transformation; nonhuman; psychosis
Date of creation
19.10.2018
Date of change
13.08.2021
Short link
https://repository.rudn.ru/en/records/article/record/765/
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