Thalamic versus midbrain tremor; two distinct types of Holmes’ Tremor: a review of 17 cases

Introduction: Holmes Tremor (HT) is a unique and debilitating movement disorder. It usually results from lesions of the midbrain and its connection but can also result from posterior thalamic injury. Clinical examination can help lesion localization between these two areas. We studied the clinical features and their radiological correlations to distinguish midbrain HT (HT-m) from thalamic HT (HT-t). Methods: Retrospective review of 17 patients with a HT-type presentation was conducted. Tremor characteristics, associated clinical signs and radiological findings were studied. Results: Eleven patients had a myorythmic rest tremor, large amplitude proximal tremor with goal-directed worsening, with or without mild distal dystonic posturing, representing HT-m. Six patients had slow, large amplitude proximal tremors and distal choreathetoid movements, significant proximal/distal dystonic posturing, associated with proprioceptive sensory loss, representing HT-t. Haemorrhagic lesions were the predominant cause of HT-m; whereas, ischaemia was more commonly associated with HT-t. Conclusion: When assessing patients with HT, attentiveness to the presence of associated signs in the affected limb, such as a proprioceptive sensory deficits and additional movement disorders, can aid lesion localisation, which can have implications for management. © 2021, Crown.

Authors
Nsengiyumva N. 1, 2 , Barakat A.3 , Macerollo A.4 , Pullicino R.3 , Bleakley A.3 , Bonello M.4 , Ellis R.J.B.4 , Alusi S.H.4
Publisher
Springer Science and Business Media Deutschland GmbH
Status
Published
Year
2021
Organizations
  • 1 Department of Neurology, People’s Friendship University of Russia, Moscow, Russian Federation
  • 2 Department of Medicine, Hope Africa University, Bujumbura, Burundi
  • 3 Department of Neuroradiology, The Walton Centre NHS Foundation Trust, Liverpool, United Kingdom
  • 4 Department of Neurology, The Walton Centre NHS Foundation Trust, Liverpool, United Kingdom
Keywords
Holmes' Tremor; Stroke; Thalamic tremor
Date of creation
20.07.2021
Date of change
20.07.2021
Short link
https://repository.rudn.ru/en/records/article/record/74475/
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