Growth of Mesenchymal Stem Cells on Poly(3-Hydroxybutyrate) Scaffolds Loaded with Simvastatin

We studied the effect of porous composite scaffolds based on poly(3-hydroxybutyrate) (PHB) loaded with simvastatin on the growth and differentiation of mesenchymal stem cells. The scaffolds have a suitable microstructure (porosity and pore size) and physicochemical properties to support the growth of mesenchymal stem cells. Scaffold loading with simvastatin suppressed cell growth and increased alkaline phosphatase activity, which can attest to their osteoinductive properties. © 2021, Springer Science+Business Media, LLC, part of Springer Nature.

Authors
Akoulina E.A.1 , Demianova I.V.1 , Zharkova I.I. 1 , Voinova V.V.1 , Zhuikov V.A.2 , Khaydapova D.D. 3 , Chesnokova D.V.1 , Menshikh K.A.1 , Dudun A.A.2 , Makhina T.K.2 , Bonartseva G.A. 2 , Volkov A.V. 3 , Asfarov T.F. 3 , Ivanov S.Y. 3, 4 , Shaitan K.V.1 , Bonartsev A.P. 1, 2
Journal
Bulletin of Experimental Biology and Medicine
Publisher
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Number of issue
1
Language
English
Pages
172-177
Status
Published
Link
External link
DOI
10.1007/s10517-021-05190-8
Volume
171
Year
2021
Organizations
  • 1 Faculty of Biology, M. V. Moscow State University, Moscow, Russian Federation
  • 2 A. N. Bach Institute of Biochemistry, Federal Research Centre Fundamentals of Biotechnology, Russian Academy of Sciences, Moscow, Russian Federation
  • 3 The Peoples’ Friendship University of Russia (RUDN University), Moscow, Russian Federation
  • 4 I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation
Keywords
hydroxyapatite; osteoinductive; poly(3-hydroxybutyrate); scaffolds; simvastatin
Date of creation
20.07.2021
Date of change
27.08.2021
Short link
https://repository.rudn.ru/en/records/article/record/74311/
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